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Target
5-lipoxygenase
Ligand
BDBM50060859
Substrate
n/a
Meas. Tech.
ChEMBL_157766 (CHEMBL767669)
IC50
7000±n/a nM
Citation
 Müller, K; Prinz, H; Gawlik, I; Ziereis, K; Huang, HS Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem 40:3773-80 (1997) [PubMed]  Article 
Target
Name:
5-lipoxygenase
Synonyms:
Arachidonate 5-lipoxygenase
Type:
PROTEIN
Mol. Mass.:
49994.23
Organism:
Bos taurus
Description:
ChEMBL_157766
Residue:
430
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGDIQLIKIEKRKYWFHDDWYLKYITVKTPCGDYIEFPCYRWISGEGEIVLRDGQAKLACDDQIHVLKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWSDFADFEKIFVRISNTISERVMNHWQEDRMFGYQFLNGCNPVMIQRCLKLPDNLPVTTEMVECSLERQLTLEQEIEQGNIFIVDFKLLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQVPGEENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGG
  
Inhibitor
Name:
BDBM50060859
Synonyms:
4,5-Dihydroxy-10-oxo-9,10-dihydro-anthracene-9-carbaldehyde | CHEMBL123787
Type:
Small organic molecule
Emp. Form.:
C15H10O4
Mol. Mass.:
254.2375
SMILES:
Oc1cccc2C(C=O)c3cccc(O)c3C(=O)c12
Structure:
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