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Target
Maternal embryonic leucine zipper kinase
Ligand
BDBM50508597
Substrate
n/a
Meas. Tech.
ChEMBL_1833238 (CHEMBL4333246)
IC50
>5000±n/a nM
Citation
 Boutard, N; Sabiniarz, A; Czerwi?ska, K; Jarosz, M; Cierpich, A; Kolasi?ska, E; Wiklik, K; Gluza, K; Commandeur, C; Buda, A; Stasiowska, A; Bobowska, A; Galek, M; Fabritius, CH; Bugaj, M; Palacz, E; Mazan, A; Zar?bski, A; Krawczy?ska, K; ?urawska, M; Zawadzki, P; Milik, M; W?grzyn, P; Dobrza?ska, M; Brzózka, K; Kowalczyk, P 5-Keto-3-cyano-2,4-diaminothiophenes as selective maternal embryonic leucine zipper kinase inhibitors. Bioorg Med Chem Lett 29:607-613 (2019) [PubMed]  Article 
Target
Name:
Maternal embryonic leucine zipper kinase
Synonyms:
KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)
Type:
Enzyme
Mol. Mass.:
74665.45
Organism:
Homo sapiens (Human)
Description:
Q14680
Residue:
651
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
  
Inhibitor
Name:
BDBM50508597
Synonyms:
CHEMBL4560455
Type:
Small organic molecule
Emp. Form.:
C14H14N4OS
Mol. Mass.:
286.352
SMILES:
CC(C)Nc1sc(C(=O)c2cccnc2)c(N)c1C#N
Structure:
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