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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50062994
Substrate
n/a
Meas. Tech.
ChEMBL_159631 (CHEMBL881815)
IC50
1.5±n/a nM
Citation
 Kempf, DJ; Sham, HL; Marsh, KC; Flentge, CA; Betebenner, D; Green, BE; McDonald, E; Vasavanonda, S; Saldivar, A; Wideburg, NE; Kati, WM; Ruiz, L; Zhao, C; Fino, L; Patterson, J; Molla, A; Plattner, JJ; Norbeck, DW Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy. J Med Chem 41:602-17 (1998) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50062994
Synonyms:
((1S,3S,4S)-1-Benzyl-3-hydroxy-4-{2-[3-(2-isopropyl-thiazol-4-ylmethyl)-3-methyl-ureido]-3-methyl-butyrylamino}-5-phenyl-pentyl)-carbamic acid 2-isopropyl-thiazol-5-ylmethyl ester | CHEMBL351145
Type:
Small organic molecule
Emp. Form.:
C40H54N6O5S2
Mol. Mass.:
763.024
SMILES:
CC(C)C(NC(=O)N(C)Cc1csc(n1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)OCc1cnc(s1)C(C)C
Structure:
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