Reaction Details Report a problem with these data
Target
Matrilysin
Ligand
BDBM50063132
Substrate
n/a
Meas. Tech.
ChEMBL_105063 (CHEMBL711309)
IC50
>1000±n/a nM
Citation
 Tamura, Y; Watanabe, F; Nakatani, T; Yasui, K; Fuji, M; Komurasaki, T; Tsuzuki, H; Maekawa, R; Yoshioka, T; Kawada, K; Sugita, K; Ohtani, M Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J Med Chem 41:640-9 (1998) [PubMed]  Article 
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM50063132
Synonyms:
(R)-3-Methyl-2-(4'-methylsulfanyl-biphenyl-4-sulfonylamino)-butyric acid | CHEMBL440921
Type:
Small organic molecule
Emp. Form.:
C18H21NO4S2
Mol. Mass.:
379.494
SMILES:
CSc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Structure:
Search PDB for entries with ligand similarity: