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Target
C-C chemokine receptor type 2
Ligand
BDBM50089354
Substrate
n/a
Meas. Tech.
ChEMBL_1839508 (CHEMBL4339723)
IC50
0.700000±n/a nM
Citation
 Yang, MG; Xiao, Z; Cherney, RJ; Tebben, AJ; Batt, DG; Brown, GD; Chen, J; Cvijic, ME; Dabros, M; Duncia, JV; Galella, M; Gardner, DS; Khandelwal, P; Ko, SS; Malley, MF; Mo, R; Pang, J; Rose, AV; Santella, JB; Shi, H; Srivastava, A; Traeger, SC; Wang, B; Xu, S; Zhao, R; Barrish, JC; Mandlekar, S; Zhao, Q; Carter, PH Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672. ACS Med Chem Lett 10:300-305 (2019) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50089354
Synonyms:
CHEMBL3577945
Type:
Small organic molecule
Emp. Form.:
C26H36F3N5O
Mol. Mass.:
491.5921
SMILES:
CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(cc23)C(F)(F)F)C1=O)N(C)C(C)C |r|
Structure:
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