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Target
Dihydrofolate reductase
Ligand
BDBM50063993
Substrate
n/a
Meas. Tech.
ChEMBL_54945 (CHEMBL669016)
IC50
12300±n/a nM
Citation
 Gangjee, A; Guo, X; Queener, SF; Cody, V; Galitsky, N; Luft, JR; Pangborn, W Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines. J Med Chem 41:1263-71 (1998) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50063993
Synonyms:
5-((naphthalen-2-ylthio)methyl)furo[2,3-d]pyrimidine-2,4-diamine | 5-(Naphthalen-2-ylsulfanylmethyl)-furo[2,3-d]pyrimidine-2,4-diamine | CHEMBL283311
Type:
Small organic molecule
Emp. Form.:
C17H14N4OS
Mol. Mass.:
322.384
SMILES:
Nc1nc(N)c2c(CSc3ccc4ccccc4c3)coc2n1
Structure:
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