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Target
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Ligand
BDBM50509986
Substrate
n/a
Meas. Tech.
ChEMBL_1839878 (CHEMBL4340093)
IC50
25000±n/a nM
Citation
 Coluccia, A; La Regina, G; Naccarato, V; Nalli, M; Orlando, V; Biagioni, S; De Angelis, ML; Baiocchi, M; Gautier, C; Gianni, S; Di Pastena, F; Di Magno, L; Canettieri, G; Coluccia, AML; Silvestri, R Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents. ACS Med Chem Lett 10:499-503 (2019) [PubMed]  Article 
Target
Name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Synonyms:
EBP50 | Ezrin-radixin-moesin-binding phosphoprotein 50 | NHERF | NHERF-1 | NHERF1 | NHRF1_HUMAN | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Regulatory cofactor of Na(+)/H(+) exchanger | SLC9A3R1 | Sodium-hydrogen exchanger regulatory factor 1 | Solute carrier family 9 isoform A3 regulatory factor 1
Type:
PROTEIN
Mol. Mass.:
38862.94
Organism:
Homo sapiens
Description:
ChEMBL_118875
Residue:
358
Sequence:
MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL
  
Inhibitor
Name:
BDBM50509986
Synonyms:
CHEMBL4453345
Type:
Small organic molecule
Emp. Form.:
C17H15ClN2O2
Mol. Mass.:
314.766
SMILES:
OCc1ccc(CNC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Structure:
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