Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 4 group A member 2
Ligand
BDBM50517830
Substrate
n/a
Meas. Tech.
ChEMBL_1869814 (CHEMBL4370880)
EC50
1.2±n/a nM
Citation
 Lesuisse, D; Malanda, A; Peyronel, JF; Evanno, Y; Lardenois, P; De-Peretti, D; Abécassis, PY; Barnéoud, P; Brunel, P; Burgevin, MC; Cegarra, C; Auger, F; Dommergue, A; Lafon, C; Even, L; Tsi, J; Luc, TPH; Almario, A; Olivier, A; Castel, MN; Taupin, V; Rooney, T; Vigé, X Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease. Bioorg Med Chem Lett 29:929-932 (2019) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 4 group A member 2
Synonyms:
NR4A2_MOUSE | NUR-related factor 1 | Nr4a2 | Nuclear receptor subfamily 4 group A member 2 | Nurr1 | Orphan nuclear receptor NURR1
Type:
PROTEIN
Mol. Mass.:
66605.74
Organism:
Mus musculus
Description:
ChEMBL_116964
Residue:
598
Sequence:
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPSTPSFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQDPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
  
Inhibitor
Name:
BDBM50517830
Synonyms:
CHEMBL4475835
Type:
Small organic molecule
Emp. Form.:
C19H12F2N4O
Mol. Mass.:
350.3216
SMILES:
Fc1cccc(NC(=O)c2cn3cc(ccc3n2)-c2ccccn2)c1F
Structure:
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