Reaction Details Report a problem with these data
Target
Cysteine proteinase falcipain 3
Ligand
BDBM50529718
Substrate
n/a
Meas. Tech.
ChEMBL_1909561 (CHEMBL4412007)
IC50
6670±n/a nM
Citation
 Gao, C; Chang, L; Xu, Z; Yan, XF; Ding, C; Zhao, F; Wu, X; Feng, LS Recent advances of tetrazole derivatives as potential anti-tubercular and anti-malarial agents. Eur J Med Chem 163:404-412 (2019) [PubMed]  Article 
Target
Name:
Cysteine proteinase falcipain 3
Synonyms:
Cysteine protease falcipain-3
Type:
Protein
Mol. Mass.:
56666.98
Organism:
Plasmodium falciparum
Description:
Q9NAW4
Residue:
492
Sequence:
MEYHMEYSPNEVIKQEREVFVGKEKSGSKFKRKRSIFIVLTVSICFMFALMLFYFTRNENNKTLFTNSLSNNINDDYIINSLLKSESGKKFIVSKLEELISSYDKEKKMRTTGAEENNMNMNGIDDKDNKSVSFVNKKNGNLKVNNNNQVSYSNLFDTKFLMDNLETVNLFYIFLKENNKKYETSEEMQKRFIIFSENYRKIELHNKKTNSLYKRGMNKFGDLSPEEFRSKYLNLKTHGPFKTLSPPVSYEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVGSVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSNLPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECGAAPNHAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTCSIGTEAYVPLLE
  
Inhibitor
Name:
BDBM50529718
Synonyms:
CHEMBL4582597
Type:
Small organic molecule
Emp. Form.:
C24H25N5O2
Mol. Mass.:
415.4876
SMILES:
CCCCOc1ccc(cc1)-c1nnn(CC(=O)Nc2c(C)ccc3ccccc23)n1
Structure:
Search PDB for entries with ligand similarity: