Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50531271
Substrate
n/a
Meas. Tech.
ChEMBL_1914749 (CHEMBL4417332)
EC50
10200±n/a nM
Citation
 Liang, JH; Luan, ZL; Tian, XG; Zhao, WY; Wang, YL; Sun, CP; Huo, XK; Deng, S; Zhang, BJ; Zhang, ZJ; Ma, XC Uncarialins A-I, Monoterpenoid Indole Alkaloids from  J Nat Prod 82:3302-3310 (2019) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50531271
Synonyms:
CHEMBL4463843
Type:
Small organic molecule
Emp. Form.:
C27H32N2O10
Mol. Mass.:
544.5504
SMILES:
[H][C@]12CN3CCc4c([nH]c5ccccc45)[C@]3(C[C@]3([H])C(=CO[C@@H](O[C@]4([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@]13[H])C(=O)OC)O2 |r,c:22|
Structure:
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