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Target
Stromelysin-1
Ligand
BDBM50090382
Substrate
n/a
Meas. Tech.
ChEMBL_104880 (CHEMBL709178)
Ki
1430±n/a nM
Citation
 Salvino, JM; Mathew, R; Kiesow, T; Narensingh, R; Mason, HJ; Dodd, A; Groneberg, R; Burns, CJ; McGeehan, G; Kline, J; Orton, E; Tang, SY; Morrisette, M; Labaudininiere, R Solid-phase synthesis of an arylsulfone hydroxamate library. Bioorg Med Chem Lett 10:1637-40 (2000) [PubMed]  Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50090382
Synonyms:
4-Benzyloxy-N-hydroxy-3-(4-methoxy-benzenesulfonyl)-butyramide | CHEMBL45208
Type:
Small organic molecule
Emp. Form.:
C18H21NO6S
Mol. Mass.:
379.427
SMILES:
COc1ccc(cc1)S(=O)(=O)C(COCc1ccccc1)CC(=O)NO
Structure:
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