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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50095399
Substrate
n/a
Meas. Tech.
ChEMBL_148190 (CHEMBL754534)
IC50
248±n/a nM
Citation
 Redman, AM; Johnson, JS; Dally, R; Swartz, S; Wild, H; Paulsen, H; Caringal, Y; Gunn, D; Renick, J; Osterhout, M; Kingery-Wood, J; Smith, RA; Lee, W; Dumas, J; Wilhelm, SM; Housley, TJ; Bhargava, A; Ranges, GE; Shrikhande, A; Young, D; Bombara, M; Scott, WJ p38 kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas. Bioorg Med Chem Lett 11:9-12 (2001) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50095399
Synonyms:
5-tert-Butyl-3-(3-p-tolyl-ureido)-thiophene-2-carboxylic acid methyl ester | CHEMBL279377 | methyl 5-tert-butyl-3-(3-p-tolylureido)thiophene-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H22N2O3S
Mol. Mass.:
346.444
SMILES:
COC(=O)c1sc(cc1NC(=O)Nc1ccc(C)cc1)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: