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Target
Urokinase-type plasminogen activator
Ligand
BDBM50015234
Substrate
n/a
Meas. Tech.
ChEMBL_226008 (CHEMBL842149)
Ki
14400±n/a nM
Citation
 Enyedy, IJ; Lee, SL; Kuo, AH; Dickson, RB; Lin, CY; Wang, S Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase. J Med Chem 44:1349-55 (2001) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50015234
Synonyms:
4,4''[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE | 4-[6-(4-Carbamimidoyl-phenoxy)-hexyloxy]-benzamidine | 4-{6-[4-amino(imino)methylphenoxy]hexyloxy}phenyl-iminomethanamine | 4-{6-[4-ammino(imino)methylphenoxy]hexyloxy}phenyl-iminomethanammine | CHEMBL25105 | Hexamidine | US9138393, Hexamidine diisethionate | US9144538, Hexamidine diisethionate
Type:
Small organic molecule
Emp. Form.:
C20H26N4O2
Mol. Mass.:
354.446
SMILES:
NC(=N)c1ccc(OCCCCCCOc2ccc(cc2)C(N)=N)cc1
Structure:
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