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Target
Carnitine O-palmitoyltransferase 1, muscle isoform
Ligand
BDBM50101589
Substrate
n/a
Meas. Tech.
ChEMBL_46323 (CHEMBL660891)
IC50
3800±n/a nM
Citation
 Giannessi, F; Chiodi, P; Marzi, M; Minetti, P; Pessotto, P; De Angelis, F; Tassoni, E; Conti, R; Giorgi, F; Mabilia, M; Dell'Uomo, N; Muck, S; Tinti, MO; Carminati, P; Arduini, A Reversible carnitine palmitoyltransferase inhibitors with broad chemical diversity as potential antidiabetic agents. J Med Chem 44:2383-6 (2001) [PubMed]  Article 
Target
Name:
Carnitine O-palmitoyltransferase 1, muscle isoform
Synonyms:
CPT1B_RAT | Carnitine palmitoyltransferase 1B | Cpt1b
Type:
PROTEIN
Mol. Mass.:
88241.28
Organism:
Rattus norvegicus
Description:
ChEMBL_887447
Residue:
772
Sequence:
MAEAHQAVAFQFTVTPDGVDFRLSREALRHIYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVVMATVGSNYCKVDISMGLVHCIQRCLPTRYGSYGTPQTETLLSMVIFSTGVWATGIFLFRQTLKLLLSYHGWMFEMHSKTSHATKIWAICVRLLSSRRPMLYSFQTSLPKLPVPSVPATIHRYLDSVRPLLDDEAYFRMESLAKEFQDKIAPRLQKYLVLKSWWATNYVSDWWEEYVYLRGRSPIMVNSNYYAMDFVLIKNTSQQAARLGNTVHAMIMYRRKLDREEIKPVMALGMVPMCSYQMERMFNTTRIPGKETDLLQHLSESRHVAVYHKGRFFKVWLYEGSCLLKPRDLEMQFQRILDDTSPPQPGEEKLAALTAGGRVEWAEARQKFFSSGKNKMSLDTIERAAFFVALDEDSHCYNPDDEASLSLYGKSLLHGNCYNRWFDKSFTLISCKNGQLGLNTEHSWADAPIIGHLWEFVLATDTFHLGYTETGHCVGEPNTKLPPPQRMQWDIPEQCQTAIENSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDKGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVRAMMTGSHKKQDLQDLFRKASEKHQNMYRLAMTGAGIDRHLFCLYIVSKYLGVRSPFLDEVLSEPWSLSTSQIPQFQICMFDPKQYPNHLGAGGGFGPVADHGYGVSYMIAGENTMFFHVSSKLSSSETNALRFGNHIRQALLDIADLFKISKTDS
  
Inhibitor
Name:
BDBM50101589
Synonyms:
CHEMBL77174 | [3-Carboxy-2-(nonylaminosulphonyl-amino)-propyl]-trimethyl-ammonium
Type:
Small organic molecule
Emp. Form.:
C16H35N3O4S
Mol. Mass.:
365.532
SMILES:
CCCCCCCCCNS(=O)(=O)NC(CC([O-])=O)C[N+](C)(C)C
Structure:
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