Reaction Details Report a problem with these data
Target
Serine/threonine-protein phosphatase 2A activator
Ligand
BDBM50544440
Substrate
n/a
Meas. Tech.
ChEMBL_1992579 (CHEMBL4626314)
IC50
>30000±n/a nM
Citation
 Ruddraraju, KV; Aggarwal, D; Niu, C; Baker, EA; Zhang, RY; Wu, L; Zhang, ZY Highly Potent and Selective  J Med Chem 63:9212-9227 (2020) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase 2A activator
Synonyms:
5.2.1.8 | PPP2R4 | PTPA | PTPA_HUMAN | Phosphotyrosyl phosphatase activator | Protein phosphatase 2A regulatory subunit B | Protein phosphatase 2A regulatory subunit B' | Serine/threonine-protein phosphatase 2A activator | Serine/threonine-protein phosphatase 2A regulatory subunit 4
Type:
n/a
Mol. Mass.:
40662.53
Organism:
Homo sapiens (Human)
Description:
Q15257
Residue:
358
Sequence:
MAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG
  
Inhibitor
Name:
BDBM50544440
Synonyms:
CHEMBL4647367 | US11192850, Entry 4t
Type:
Small organic molecule
Emp. Form.:
C17H9ClF3NO3
Mol. Mass.:
367.706
SMILES:
OC(=O)C(=O)Nc1ccc(cc1)C#Cc1ccc(cc1Cl)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: