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Target
Transcriptional enhancer factor TEF-3
Ligand
BDBM50547131
Substrate
n/a
Meas. Tech.
ChEMBL_2017235 (CHEMBL4670813)
IC50
3700±n/a nM
Citation
 Karatas, H; Akbarzadeh, M; Adihou, H; Hahne, G; Pobbati, AV; Yihui Ng, E; Guéret, SM; Sievers, S; Pahl, A; Metz, M; Zinken, S; Dötsch, L; Nowak, C; Thavam, S; Friese, A; Kang, C; Hong, W; Waldmann, H Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket. J Med Chem 63:11972-11989 (2020) [PubMed]  Article 
Target
Name:
Transcriptional enhancer factor TEF-3
Synonyms:
RTEF1 | TCF13L1 | TEA domain family member 4 | TEAD-4 | TEAD4 | TEAD4_HUMAN | TEF3 | Transcription factor 13-like 1 | Transcription factor RTEF-1 | Transcriptional enhancer factor TEF-3
Type:
PROTEIN
Mol. Mass.:
48333.01
Organism:
Homo sapiens
Description:
ChEMBL_118073
Residue:
434
Sequence:
MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
  
Inhibitor
Name:
BDBM50547131
Synonyms:
CHEMBL4800702
Type:
Small organic molecule
Emp. Form.:
C18H15BrN2O4
Mol. Mass.:
403.227
SMILES:
OCc1cc(=O)c(O)c(o1)C(Nc1ccccn1)c1ccc(Br)cc1
Structure:
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