Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50113205
Substrate
n/a
Meas. Tech.
ChEMBL_50979 (CHEMBL663522)
Ki
650±n/a nM
Citation
 Wilson, DM; Termin, AP; Mao, L; Ramirez-Weinhouse, MM; Molteni, V; Grootenhuis, PD; Miller, K; Keim, S; Wise, G Arylamidrazones as novel corticotropin releasing factor receptor antagonists. J Med Chem 45:2123-6 (2002) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50113205
Synonyms:
3-methylphenyl (1E)-N-(2-cyanophenyl)-2-oxopropanehydrazonoate | CHEMBL70143
Type:
Small organic molecule
Emp. Form.:
C17H15N3O2
Mol. Mass.:
293.3199
SMILES:
CC(=O)C(Oc1cccc(C)c1)=NNc1ccccc1C#N |w:12.13|
Structure:
Search PDB for entries with ligand similarity: