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Target
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Ligand
BDBM50558481
Substrate
n/a
Meas. Tech.
ChEMBL_2063775 (CHEMBL4719028)
IC50
83000±n/a nM
Citation
 He, R; Wang, J; Yu, ZH; Zhang, RY; Liu, S; Wu, L; Zhang, ZY Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism. J Med Chem 59:9094-9106 (2016) [PubMed]  Article 
Target
Name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Synonyms:
CTD phosphatase SSU72 | PNAS-120 | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 | SSU72 | SSU72_HUMAN
Type:
Enzyme
Mol. Mass.:
22567.68
Organism:
Homo sapiens (Human)
Description:
Q9NP77
Residue:
194
Sequence:
MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY
  
Inhibitor
Name:
BDBM50558481
Synonyms:
CHEMBL4783639
Type:
Small organic molecule
Emp. Form.:
C16H11F6NO4S
Mol. Mass.:
427.318
SMILES:
OS(=O)(=O)C(C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ccccc1
Structure:
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