Reaction Details Report a problem with these data
Target
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Ligand
BDBM50558483
Substrate
n/a
Meas. Tech.
ChEMBL_2063775 (CHEMBL4719028)
IC50
>200000±n/a nM
Citation
 He, R; Wang, J; Yu, ZH; Zhang, RY; Liu, S; Wu, L; Zhang, ZY Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism. J Med Chem 59:9094-9106 (2016) [PubMed]  Article 
Target
Name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Synonyms:
CTD phosphatase SSU72 | PNAS-120 | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 | SSU72 | SSU72_HUMAN
Type:
Enzyme
Mol. Mass.:
22567.68
Organism:
Homo sapiens (Human)
Description:
Q9NP77
Residue:
194
Sequence:
MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY
  
Inhibitor
Name:
BDBM50558483
Synonyms:
CHEMBL4778085
Type:
Small organic molecule
Emp. Form.:
C17H14N2O4S
Mol. Mass.:
342.369
SMILES:
OS(=O)(=O)C(C(=O)Nc1cnc2ccccc2c1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: