Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 5
Ligand
BDBM50121837
Substrate
n/a
Meas. Tech.
ChEBML_49693
IC50
0.400000±n/a nM
Citation
 Lynch, CL; Willoughby, CA; Hale, JJ; Holson, EJ; Budhu, RJ; Gentry, AL; Rosauer, KG; Caldwell, CG; Chen, P; Mills, SG; MacCoss, M; Berk, S; Chen, L; Chapman, KT; Malkowitz, L; Springer, MS; Gould, SL; DeMartino, JA; Siciliano, SJ; Cascieri, MA; Carella, A; Carver, G; Holmes, K; Schleif, WA; Danzeisen, R; Hazuda, D; Kessler, J; Lineberger, J; Miller, M; Emini, EA 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains. Bioorg Med Chem Lett 13:119-23 (2002) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50121837
Synonyms:
(2R)-3-cyclopropyl-2-((3S,4S)-3-(3-fluorophenyl)-4-((4-(3-(4-fluorophenyl)-3-hydroxypropyl)piperidin-1-yl)methyl)pyrrolidin-1-yl)propanoic acid | 3-Cyclopropyl-2-((S)-3-(3-fluoro-phenyl)-4-{4-[(R)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-piperidin-1-ylmethyl}-pyrrolidin-1-yl)-propionic acid | CHEMBL20453
Type:
Small organic molecule
Emp. Form.:
C31H40F2N2O3
Mol. Mass.:
526.6577
SMILES:
OC(CCC1CCN(C[C@H]2CN(C[C@@H]2c2cccc(F)c2)[C@H](CC2CC2)C(O)=O)CC1)c1ccc(F)cc1 |r|
Structure:
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