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Target
Endoplasmic reticulum aminopeptidase 2
Ligand
BDBM50570142
Substrate
n/a
Meas. Tech.
ChEMBL_2111174 (CHEMBL4820024)
IC50
22000±n/a nM
Citation
 Laura, M; Ronan, G; Vy, LB; Valentin, G; Omar, CA; Virgyl, C; Piveteau, C; Melissa, R; Charlotte, F; Sandrine, W; Julie, C; Julie, DR; Damien, B; Florence, L; Peter, VE; Benoit, D; Rebecca, DP Modulators of hERAP2 discovered by high-throughput screening. Eur J Med Chem 211:0 (2021) [PubMed]  Article 
Target
Name:
Endoplasmic reticulum aminopeptidase 2
Synonyms:
Aminopeptidase | ERAP2 | ERAP2_HUMAN | LRAP
Type:
PROTEIN
Mol. Mass.:
110463.90
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1473169
Residue:
960
Sequence:
MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT
  
Inhibitor
Name:
BDBM50570142
Synonyms:
CHEMBL4878060
Type:
Small organic molecule
Emp. Form.:
C30H32N4O3
Mol. Mass.:
496.6001
SMILES:
OC(=O)CN(CC(=O)N1CCN(Cc2ccccc2)C[C@@H]1Cc1c[nH]c2ccccc12)c1ccccc1 |r|
Structure:
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