Reaction Details Report a problem with these data
Target
Endoplasmic reticulum aminopeptidase 2
Ligand
BDBM50076744
Substrate
n/a
Meas. Tech.
ChEMBL_2111180 (CHEMBL4820030)
IC50
755000±n/a nM
Citation
 Laura, M; Ronan, G; Vy, LB; Valentin, G; Omar, CA; Virgyl, C; Piveteau, C; Melissa, R; Charlotte, F; Sandrine, W; Julie, C; Julie, DR; Damien, B; Florence, L; Peter, VE; Benoit, D; Rebecca, DP Modulators of hERAP2 discovered by high-throughput screening. Eur J Med Chem 211:0 (2021) [PubMed]  Article 
Target
Name:
Endoplasmic reticulum aminopeptidase 2
Synonyms:
Aminopeptidase | ERAP2 | ERAP2_HUMAN | LRAP
Type:
PROTEIN
Mol. Mass.:
110463.90
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1473169
Residue:
960
Sequence:
MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT
  
Inhibitor
Name:
BDBM50076744
Synonyms:
CHEMBL3416733
Type:
Small organic molecule
Emp. Form.:
C27H37N4O4P
Mol. Mass.:
512.5808
SMILES:
CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r|
Structure:
Search PDB for entries with ligand similarity: