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Target
Transient receptor potential cation channel subfamily M member 5
Ligand
BDBM50571598
Substrate
n/a
Meas. Tech.
ChEMBL_2115164 (CHEMBL4824105)
EC50
490±n/a nM
Citation
 Barilli, A; Aldegheri, L; Bianchi, F; Brault, L; Brodbeck, D; Castelletti, L; Feriani, A; Lingard, I; Myers, R; Nola, S; Piccoli, L; Pompilio, D; Raveglia, LF; Salvagno, C; Tassini, S; Virginio, C; Sabat, M From High-Throughput Screening to Target Validation: Benzo[ J Med Chem 64:5931-5955 (2021) [PubMed]  Article 
Target
Name:
Transient receptor potential cation channel subfamily M member 5
Synonyms:
LTRPC5 | LTRPC5 | LTrpC-5 | Long transient receptor potential channel 5 | MLSN1- and TRP-related gene 1 protein | MTR1 | TRPM5 | TRPM5_HUMAN | Transient receptor potential cation channel subfamily M member 5
Type:
PROTEIN
Mol. Mass.:
131454.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103787
Residue:
1165
Sequence:
MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQLVAADHRGGLDGWEQPGAGQPPSDT
  
Inhibitor
Name:
BDBM50571598
Synonyms:
CHEMBL4874619
Type:
Small organic molecule
Emp. Form.:
C12H8F3N3S2
Mol. Mass.:
315.337
SMILES:
FC(F)(F)c1cnc(CNc2ccc3sncc3c2)s1
Structure:
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