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Target
Plasminogen activator inhibitor 1
Ligand
BDBM50139533
Substrate
n/a
Meas. Tech.
ChEBML_155740
IC50
3500±n/a nM
Citation
 Ye, B; Chou, YL; Karanjawala, R; Lee, W; Lu, SF; Shaw, KJ; Jones, S; Lentz, D; Liang, A; Tseng, JL; Wu, Q; Zhao, Z Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1). Bioorg Med Chem Lett 14:761-5 (2004) [PubMed]  Article 
Target
Name:
Plasminogen activator inhibitor 1
Synonyms:
Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1
Type:
Enzyme
Mol. Mass.:
45064.00
Organism:
Homo sapiens (Human)
Description:
P05121
Residue:
402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
  
Inhibitor
Name:
BDBM50139533
Synonyms:
1-{4-Nitro-2-trifluoromethyl-5-[4-(3-trifluoromethyl-phenylcarbamoyl)-piperazin-1-yl]-phenyl}-piperidine-4-carboxylic acid | CHEMBL165724
Type:
Small organic molecule
Emp. Form.:
C25H25F6N5O5
Mol. Mass.:
589.4869
SMILES:
OC(=O)C1CCN(CC1)c1cc(N2CCN(CC2)C(=O)Nc2cccc(c2)C(F)(F)F)c(cc1C(F)(F)F)[N+]([O-])=O
Structure:
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