Reaction Details Report a problem with these data
Target
Plasminogen
Ligand
BDBM50144532
Substrate
n/a
Meas. Tech.
ChEBML_155587
IC50
309±n/a nM
Citation
Bisacchi, GS; Slusarchyk, WA; Bolton, SA; Hartl, KS; Jacobs, G; Mathur, A; Meng, W; Ogletree, ML; Pi, Z; Sutton, JC; Treuner, U; Zahler, R; Zhao, G; Seiler, SM Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase. Bioorg Med Chem Lett 14:2227-31 (2004) [PubMed] Article
More Info.:
Target
Name:
Plasminogen
Synonyms:
PLMN_RAT | Plasmin | Plasminogen | Plg
Type:
Protein
Mol. Mass.:
90541.87
Organism:
Rattus norvegicus
Description:
Q01177
Residue:
812
Sequence:
MDHKEIILLFLLFLKPGQGDSLDGYVSTQGASLHSLTKKQLAAGSIADCLAKCEGETDFICRSFQYHSKEQQCVIMAENSKTSSIIRMRDVILFEKRVYLSECKTGIGKGYRGTMSKTKTGVTCQKWSDTSPHVPKYSPSTHPSEGLEENYCRNPDNDEQGPWCYTTDPDQRYEYCNIPECEEECMYCSGEKYEGKISKTMSGLDCQSWDSQSPHAHGYIPAKFPSKNLKMNYCRNPDGEPRPWCFTTDPNKRWEYCDIPRCTTPPPPPGPTYQCLKGRGENYRGTVSVTASGKTCQRWSEQTPHRHNRTPENFPCKNLEENYCRNPDGETAPWCYTTDSQLRWEYCEIPSCGSSVSPDQSDSSVLPEQTPVVQECYQGNGKSYRGTSSTTNTGKKCQSWVSMTPHSHSKTPANFPDAGLEMNYCRNPDNDQRGPWCFTTDPSVRWEYCNLKRCSETGGGVAESAIVPQVPSAPGTSETDCMYGNGKEYRGKTAVTAAGTPCQEWAAQEPHSHRIFTPQTNPRAGLEKNYCRNPDGDVNGPWCYTMNPRKLYDYCNIPLCASLSSFECGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTRFSGQHFCGGTLISPEWVLTAAHCLEKSSRPEFYKVILGAHEERILGSDVQQIAVTKLVLEPNDADIALLKLSRPATITDNVIPACLPSPNYVVADRTLCYITGWGETKGTPGAGRLKEAQLPVIENKVCNRAEYLNNRVKSTELCAGHLAGGIDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRYVNWIEREMRND
Inhibitor
Name:
BDBM50144532
Synonyms:
(2S,3R)-4-Oxo-1-[4-(6-phenyl-hexanoyl)-piperazine-1-carbonyl]-3-(2-piperidin-3-yl-ethyl)-azetidine-2-carboxylic acid | BMS-354326 | CHEMBL306448
Type:
Small organic molecule
Emp. Form.:
C28H40N4O5
Mol. Mass.:
512.641
SMILES:
OC(=O)[C@@H]1[C@@H](CCC2CCCNC2)C(=O)N1C(=O)N1CCN(CC1)C(=O)CCCCCc1ccccc1