Reaction Details
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Monoacylglycerol lipase ABHD6
Ligand
BDBM50577908
Substrate
n/a
Meas. Tech.
ChEMBL_2131323 (CHEMBL4840838)
IC50
35100±n/a nM
Citation
Schafroth, MA; Mazzoccanti, G; Reynoso-Moreno, I; Erni, R; Pollastro, F; Caprioglio, D; Botta, B; Allegrone, G; Grassi, G; Chicca, A; Gasparrini, F; Gertsch, J; Carreira, EM; Appendino, G ? J Nat Prod 84:2502-2510 (2021) [PubMed] Article More Info.:
Target
Name:
Monoacylglycerol lipase ABHD6
Synonyms:
2-arachidonoylglycerol hydrolase | ABHD6 | ABHD6_HUMAN | Abhydrolase domain-containing protein 6 | Monoacylglycerol lipase ABHD6
Type:
PROTEIN
Mol. Mass.:
38341.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105457
Residue:
337
Sequence:
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYSTDNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNNFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVELLENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD
Inhibitor
Name:
BDBM50577908
Synonyms:
CHEMBL4862731
Type:
Small organic molecule
Emp. Form.:
C21H30O2
Mol. Mass.:
314.4617
SMILES:
[H][C@]12C=C(C)CC[C@@]1([H])C(C)(C)Oc1cc(CCCCC)cc(O)c21 |r,t:2|
Structure:
