Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50153954
Substrate
n/a
Meas. Tech.
ChEMBL_305170 (CHEMBL832760)
IC50
7800±n/a nM
Citation
 Moree, WJ; Kataoka, K; Ramirez-Weinhouse, MM; Shiota, T; Imai, M; Sudo, M; Tsutsumi, T; Endo, N; Muroga, Y; Hada, T; Tanaka, H; Morita, T; Greene, J; Barnum, D; Saunders, J; Kato, Y; Myers, PL; Tarby, CM Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives. Bioorg Med Chem Lett 14:5413-6 (2004) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50153954
Synonyms:
4-Methyl-thiophene-2-carboxylic acid N''-{2-[3-(4-chloro-benzylamino)-pyrrolidin-1-yl]-acetyl}-hydrazide | CHEMBL362536
Type:
Small organic molecule
Emp. Form.:
C19H23ClN4O2S
Mol. Mass.:
406.93
SMILES:
Cc1csc(c1)C(=O)NNC(=O)CN1CCC(C1)NCc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: