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Target
Cannabinoid receptor 1
Ligand
BDBM50160125
Substrate
n/a
Meas. Tech.
ChEMBL_305569 (CHEMBL827163)
IC50
3.1±n/a nM
Citation
 Meurer, LC; Finke, PE; Mills, SG; Walsh, TF; Toupence, RB; Debenham, JS; Goulet, MT; Wang, J; Tong, X; Fong, TM; Lao, J; Schaeffer, MT; Chen, J; Shen, CP; Sloan Stribling, D; Shearman, LP; Strack, AM; Van der Ploeg, LH Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists. Bioorg Med Chem Lett 15:645-51 (2005) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50160125
Synonyms:
5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-2-(3,4-difluoro-benzyloxy)-N-methyl-nicotinamide | CHEMBL181875
Type:
Small organic molecule
Emp. Form.:
C26H17Cl3F2N2O2
Mol. Mass.:
533.781
SMILES:
CNC(=O)c1cc(-c2ccc(Cl)cc2)c(nc1OCc1ccc(F)c(F)c1)-c1ccc(Cl)cc1Cl
Structure:
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