Reaction Details Report a problem with these data
Target
Histone deacetylase 7
Ligand
BDBM50593367
Substrate
n/a
Meas. Tech.
ChEMBL_2208069 (CHEMBL5121018)
IC50
6700±n/a nM
Citation
 Upadhyay, N; Tilekar, K; Safuan, S; Kumar, AP; Schweipert, M; Meyer-Almes, FJ; C S, R Multi-target weapons: diaryl-pyrazoline thiazolidinediones simultaneously targeting VEGFR-2 and HDAC cancer hallmarks. RSC Med Chem 12:1540-1554 (2021) [PubMed] 
Target
Name:
Histone deacetylase 7
Synonyms:
HD7 | HDAC7 | HDAC7A | HDAC7_HUMAN | Histone acetylase 7 (HDAC7) | Histone deacetylase 7A | Human HDAC7
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
102942.62
Organism:
Homo sapiens (Human)
Description:
Q8WUI4
Residue:
952
Sequence:
MDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
  
Inhibitor
Name:
BDBM50593367
Synonyms:
CHEMBL5183909
Type:
Small organic molecule
Emp. Form.:
C27H18Cl2FN3O4S
Mol. Mass.:
570.419
SMILES:
Fc1ccc(cc1)C1=NN(C(C1)c1ccc(Cl)c(Cl)c1)C(=O)COc1ccc(\C=C2\SC(=O)NC2=O)cc1 |t:8|
Structure:
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