Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50172146
Substrate
n/a
Meas. Tech.
ChEMBL_320783 (CHEMBL884738)
Ki
0.4±n/a nM
Citation
 Shankar, BB; Lavey, BJ; Zhou, G; Spitler, JA; Tong, L; Rizvi, R; Yang, DY; Wolin, R; Kozlowski, JA; Shih, NY; Wu, J; Hipkin, RW; Gonsiorek, W; Lunn, CA Triaryl bis-sulfones as cannabinoid-2 receptor ligands: SAR studies. Bioorg Med Chem Lett 15:4417-20 (2005) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50172146
Synonyms:
CHEMBL381669 | N-((S)-1-{4-[2-(2-Fluoro-benzenesulfonyl)-4-trifluoromethoxy-benzyl]-phenyl}-ethyl)-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C23H21F4NO5S2
Mol. Mass.:
531.54
SMILES:
C[C@H](NS(C)(=O)=O)c1ccc(Cc2ccc(OC(F)(F)F)cc2S(=O)(=O)c2ccccc2F)cc1
Structure:
Search PDB for entries with ligand similarity: