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Target
Pyruvate kinase PKM
Ligand
BDBM50081950
Substrate
n/a
Meas. Tech.
ChEMBL_2224285 (CHEMBL5137798)
IC50
1240±n/a nM
Citation
 Arora, S; Joshi, G; Chaturvedi, A; Heuser, M; Patil, S; Kumar, R A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2. J Med Chem 65:1171-1205 (2022) [PubMed] 
Target
Name:
Pyruvate kinase PKM
Synonyms:
KPYM_HUMAN | OIP3 | PK2 | PK3 | PKM | PKM2 | Pyruvate kinase (PKM2)
Type:
Protein
Mol. Mass.:
57944.31
Organism:
Homo sapiens (Human)
Description:
P14618
Residue:
531
Sequence:
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
  
Inhibitor
Name:
BDBM50081950
Synonyms:
6-Hydroxy-2-phenyl-chromen-4-one | 6-Hydroxyflavone | 6-Hydroxyflavone, 10 | 6-hydroxy-2-phenyl-4H-chromen-4-one | 6-hydroxy-flavone | CHEMBL138649 | NSC-26744
Type:
Small organic molecule
Emp. Form.:
C15H10O3
Mol. Mass.:
238.2381
SMILES:
Oc1ccc2oc(cc(=O)c2c1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: