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Target
RNA-directed RNA polymerase
Ligand
BDBM50176485
Substrate
n/a
Meas. Tech.
ChEMBL_329786 (CHEMBL864623)
IC50
2850±n/a nM
Citation
 Gopalsamy, A; Aplasca, A; Ciszewski, G; Park, K; Ellingboe, JW; Orlowski, M; Feld, B; Howe, AY Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase. Bioorg Med Chem Lett 16:457-60 (2005) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50176485
Synonyms:
((S)-5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4,5]thieno[2,3-c]pyran-1-yl)-acetic acid | CHEMBL200696
Type:
Small organic molecule
Emp. Form.:
C18H19NO3S
Mol. Mass.:
329.413
SMILES:
CCC[C@@]1(CC(O)=O)OCCc2c1sc1c(C)ccc(C#N)c21
Structure:
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