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Target
B1 bradykinin receptor
Ligand
BDBM50182221
Substrate
n/a
Meas. Tech.
ChEMBL_344573 (CHEMBL866612)
IC50
23±n/a nM
Citation
 Fotsch, C; Biddlecome, G; Biswas, K; Chen, JJ; D'Amico, DC; Groneberg, RD; Han, NB; Hsieh, FY; Kamassah, A; Kumar, G; Lester-Zeiner, D; Liu, Q; Mareska, DA; Riahi, BB; Wang, YJ; Yang, K; Zhan, J; Zhu, J; Johnson, E; Ng, G; Askew, BC A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core. Bioorg Med Chem Lett 16:2071-5 (2006) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50182221
Synonyms:
CHEMBL381366 | N-((R)-6-((tert-butylamino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-((S)-1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)acetamide
Type:
Small organic molecule
Emp. Form.:
C29H38F3N3O3S
Mol. Mass.:
565.691
SMILES:
CC(C)(C)NCc1ccc2[C@@H](CCCc2c1)NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(c1)C(F)(F)F |r|
Structure:
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