Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase RIO2
Ligand
BDBM50605905
Substrate
n/a
Meas. Tech.
ChEMBL_2253171 (CHEMBL5167381)
Kd
<200±n/a nM
Citation
 Ouyang, Y; Si, H; Zhu, C; Zhong, L; Ma, H; Li, Z; Xiong, H; Liu, T; Liu, Z; Zhang, Z; Zhang, ZM; Cai, Q Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro- J Med Chem 65:7833-7842 (2022) [PubMed] 
Target
Name:
Serine/threonine-protein kinase RIO2
Synonyms:
RIO2 | RIOK2 | RIOK2_HUMAN
Type:
PROTEIN
Mol. Mass.:
63275.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_655912
Residue:
552
Sequence:
MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEVSASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLEESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEKNRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTRTLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNIKSSLEAASFWGE
  
Inhibitor
Name:
BDBM50605905
Synonyms:
CHEMBL5184068
Type:
Small organic molecule
Emp. Form.:
C35H30N4O4
Mol. Mass.:
570.6371
SMILES:
COC1C(CC2OC1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: