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Target
Serine/threonine-protein kinase RIO2
Ligand
BDBM50605911
Substrate
n/a
Meas. Tech.
ChEMBL_2253173 (CHEMBL5167383)
Kd
49±n/a nM
Citation
 Ouyang, Y; Si, H; Zhu, C; Zhong, L; Ma, H; Li, Z; Xiong, H; Liu, T; Liu, Z; Zhang, Z; Zhang, ZM; Cai, Q Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro- J Med Chem 65:7833-7842 (2022) [PubMed] 
Target
Name:
Serine/threonine-protein kinase RIO2
Synonyms:
RIO2 | RIOK2 | RIOK2_HUMAN
Type:
PROTEIN
Mol. Mass.:
63275.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_655912
Residue:
552
Sequence:
MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEVSASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLEESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEKNRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTRTLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNIKSSLEAASFWGE
  
Inhibitor
Name:
BDBM50605911
Synonyms:
CHEMBL5192566
Type:
Small organic molecule
Emp. Form.:
C27H24F3N7O2
Mol. Mass.:
535.5204
SMILES:
COc1ccc(cn1)-c1ccc2n(C)c(=O)c3nnn(-c4ccc(N5CCNCC5)c(c4)C(F)(F)F)c3c2c1
Structure:
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