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Target
Prostaglandin D2 receptor 2
Ligand
BDBM50188308
Substrate
n/a
Meas. Tech.
ChEMBL_378634 (CHEMBL868656)
IC50
18±n/a nM
Citation
 Birkinshaw, TN; Teague, SJ; Beech, C; Bonnert, RV; Hill, S; Patel, A; Reakes, S; Sanganee, H; Dougall, IG; Phillips, TT; Salter, S; Schmidt, J; Arrowsmith, EC; Carrillo, JJ; Bell, FM; Paine, SW; Weaver, R Discovery of potent CRTh2 (DP2) receptor antagonists. Bioorg Med Chem Lett 16:4287-90 (2006) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM50188308
Synonyms:
2-(3-(8-cyanoquinolin-4-yl)-2,5-dimethyl-1H-indol-1-yl)acetic acid | CHEMBL213495
Type:
Small organic molecule
Emp. Form.:
C22H17N3O2
Mol. Mass.:
355.3893
SMILES:
Cc1c(-c2ccnc3c(cccc23)C#N)c2cc(C)ccc2n1CC(O)=O |(27.67,-17.48,;26.13,-17.49,;25.23,-18.76,;25.71,-20.22,;27.21,-20.52,;27.7,-21.97,;26.68,-23.13,;25.17,-22.82,;24.15,-23.96,;22.66,-23.66,;22.17,-22.2,;23.19,-21.06,;24.68,-21.37,;24.65,-25.42,;25.14,-26.88,;23.74,-18.28,;22.41,-19.05,;21.07,-18.28,;19.73,-19.05,;21.07,-16.73,;22.4,-15.96,;23.74,-16.73,;25.22,-16.24,;25.69,-14.78,;27.19,-14.45,;28.23,-15.59,;27.67,-12.98,)|
Structure:
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