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Found 100 with Last Name = 'teague' and Initial = 'sj'
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282772(CHEMBL290015 | SLB-606)
Affinity DataKi:  207nMAssay Description:Binding affinity of the compound towards immunophilin cytosolic protein FK506 binding protein 12 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282773(CHEMBL418618 | Macrocyclic FK506 derivative)
Affinity DataKi:  400nMAssay Description:Binding affinity of the compound towards immunophilin cytosolic protein FK506 binding protein 12 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188311(2-(3-(8-chloroquinolin-4-yl)-2,5-dimethyl-1H-indol...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188300(2-(2,5-dimethyl-3-(7-(trifluoromethyl)quinolin-4-y...)
Affinity DataIC50:  5.40nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188305(2-(2,5-dimethyl-3-(8-(trifluoromethyl)quinolin-4-y...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188309(2-(3-(8-fluoroquinolin-4-yl)-2,5-dimethyl-1H-indol...)
Affinity DataIC50:  7.10nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188307(2-(3-(7-chloroquinolin-4-yl)-2,5-dimethyl-1H-indol...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188299(2-(3-(8-methoxyquinolin-4-yl)-2,5-dimethyl-1H-indo...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188314(2-(2,5-dimethyl-3-(2-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188308(2-(3-(8-cyanoquinolin-4-yl)-2,5-dimethyl-1H-indol-...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188313(2-(2,5-dimethyl-3-(quinolin-4-yl)-1H-indol-1-yl)ac...)
Affinity DataIC50:  21nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188310(2-(2,5-dimethyl-3-(8-(methylsulfonyl)quinolin-4-yl...)
Affinity DataIC50:  23nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188302(2-(1-(7-chloroquinolin-4-yl)-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  40nMAssay Description:Inhibition of COX1-mediated platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188304(2-(3-(7-chloroquinolin-4-yl)-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  50nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188306(2-(2,5-dimethyl-3-(6-(trifluoromethyl)quinolin-4-y...)
Affinity DataIC50:  68nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188312(2-(3-(7-chloroquinolin-4-yl)-2,6-dimethyl-1H-indol...)
Affinity DataIC50:  125nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  150nMAssay Description:Inhibition at rat aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188302(2-(1-(7-chloroquinolin-4-yl)-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  180nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188307(2-(3-(7-chloroquinolin-4-yl)-2,5-dimethyl-1H-indol...)
Affinity DataIC50:  400nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188302(2-(1-(7-chloroquinolin-4-yl)-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition at recombinant human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition at rat serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition at recombinant human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition at CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188303(2-(2-methyl-1-(pyrimidin-4-yl)-1H-indol-3-yl)aceti...)
Affinity DataIC50:  5.20E+3nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011370(CHEMBL3261022)
Affinity DataEC50:  790nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011371(CHEMBL3261023)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011372(CHEMBL3261024)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011373(CHEMBL3261025)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011374(CHEMBL3261026)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011375(CHEMBL3261027)
Affinity DataEC50:  6.30E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011376(CHEMBL3261028)
Affinity DataEC50:  3.90E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011377(CHEMBL3261029)
Affinity DataEC50:  500nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011378(CHEMBL3261030)
Affinity DataEC50:  790nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011379(CHEMBL3261031)
Affinity DataEC50:  630nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011380(CHEMBL3261032)
Affinity DataEC50:  630nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011381(CHEMBL3261033)
Affinity DataEC50:  3.90E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011382(CHEMBL3261034)
Affinity DataEC50:  390nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011383(CHEMBL3261035)
Affinity DataEC50:  630nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011384(CHEMBL3261036)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011385(CHEMBL3261037)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011386(CHEMBL3261038)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011387(CHEMBL3261039)
Affinity DataEC50:  7.90E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011388(CHEMBL3261041)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011389(CHEMBL3261246)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011390(CHEMBL3261247)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011391(CHEMBL3261248)
Affinity DataEC50:  3.10E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50011392(CHEMBL3261249)
Affinity DataEC50:  3.10E+3nMAssay Description:Agonist activity at human recombinant TLR4 expressed in HEK293 cells by SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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