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Target
Prostaglandin D2 receptor 2
Ligand
BDBM50188310
Substrate
n/a
Meas. Tech.
ChEMBL_378634 (CHEMBL868656)
IC50
23±n/a nM
Citation
 Birkinshaw, TN; Teague, SJ; Beech, C; Bonnert, RV; Hill, S; Patel, A; Reakes, S; Sanganee, H; Dougall, IG; Phillips, TT; Salter, S; Schmidt, J; Arrowsmith, EC; Carrillo, JJ; Bell, FM; Paine, SW; Weaver, R Discovery of potent CRTh2 (DP2) receptor antagonists. Bioorg Med Chem Lett 16:4287-90 (2006) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM50188310
Synonyms:
2-(2,5-dimethyl-3-(8-(methylsulfonyl)quinolin-4-yl)-1H-indol-1-yl)acetic acid | CHEMBL213494
Type:
Small organic molecule
Emp. Form.:
C22H20N2O4S
Mol. Mass.:
408.47
SMILES:
Cc1c(-c2ccnc3c(cccc23)S(C)(=O)=O)c2cc(C)ccc2n1CC(O)=O |(13.57,-17.56,;12.03,-17.57,;11.12,-18.83,;11.61,-20.29,;13.11,-20.59,;13.6,-22.05,;12.57,-23.21,;11.06,-22.89,;10.05,-24.03,;8.56,-23.73,;8.07,-22.27,;9.09,-21.13,;10.58,-21.44,;10.54,-25.49,;11.04,-26.95,;11.87,-24.71,;9.2,-26.25,;9.64,-18.36,;8.31,-19.12,;6.97,-18.35,;5.64,-19.12,;6.97,-16.81,;8.3,-16.04,;9.64,-16.8,;11.12,-16.32,;11.59,-14.85,;13.09,-14.53,;14.13,-15.66,;13.57,-13.06,)|
Structure:
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