Reaction Details Report a problem with these data
Target
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Ligand
BDBM50606047
Substrate
n/a
Meas. Tech.
ChEMBL_2253497 (CHEMBL5167707)
EC50
200±n/a nM
Citation
 Huang, J; Zhang, J; Luo, B; Qiao, W; Qiu, Z; Song, R; Dai, Z; Sui, J; Xu, X; Ruan, S; Li, C; Luo, Y; Yang, T Discovery of a Novel Series of Imipridone Compounds as  J Med Chem 65:7629-7655 (2022) [PubMed] 
Target
Name:
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Synonyms:
3.4.21.92 | ATP-dependent Clp protease proteolytic subunit, mitochondrial | CLPP | CLPP_HUMAN | Endopeptidase Clp
Type:
PROTEIN
Mol. Mass.:
30185.26
Organism:
Homo sapiens
Description:
ChEMBL_119055
Residue:
277
Sequence:
MWPGILVGGARVASCRYPALGPRLAAHFPAQRPPQRTLQNGLALQRCLHATATRALPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPTLVQKEPVEAAPAAEPVPAST
  
Inhibitor
Name:
BDBM50606047
Synonyms:
CHEMBL5191392
Type:
Small organic molecule
Emp. Form.:
C23H22BrFN4O
Mol. Mass.:
469.349
SMILES:
Fc1ccc(CN2CCn3c2nc(=O)c2CN(Cc4ccccc4)CCc32)cc1Br
Structure:
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