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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50189642
Substrate
n/a
Meas. Tech.
ChEMBL_368413 (CHEMBL870503)
IC50
32±n/a nM
Citation
 Combs, AP; Zhu, W; Crawley, ML; Glass, B; Polam, P; Sparks, RB; Modi, D; Takvorian, A; McLaughlin, E; Yue, EW; Wasserman, Z; Bower, M; Wei, M; Rupar, M; Ala, PJ; Reid, BM; Ellis, D; Gonneville, L; Emm, T; Taylor, N; Yeleswaram, S; Li, Y; Wynn, R; Burn, TC; Hollis, G; Liu, PC; Metcalf, B Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic. J Med Chem 49:3774-89 (2006) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50189642
Synonyms:
CHEMBL210836 | N-(1S)-1-(1H-benzimidazol-2yl)-2-4-[(5S)-1,1-dioxo-3-oxoisothiazolidin-5-yl]phenylethyl)benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C24H21N4O5S2
Mol. Mass.:
509.578
SMILES:
O=C1C[C@@H](c2ccc(C[C@H](NS(=O)(=O)c3ccccc3)c3nc4ccccc4[nH]3)cc2)S(=O)(=O)[N-]1
Structure:
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