Reaction Details Report a problem with these data
Target
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Ligand
BDBM50607110
Substrate
n/a
Meas. Tech.
ChEMBL_2262156 (CHEMBL5217167)
IC50
>100000±n/a nM
Citation
 He, R; Wang, J; Yu, ZH; Moyers, JS; Michael, MD; Durham, TB; Cramer, JW; Qian, Y; Lin, A; Wu, L; Noinaj, N; Barrett, DG; Zhang, ZY Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors. J Med Chem 65:13892-13909 (2022) [PubMed] 
Target
Name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Synonyms:
CTD phosphatase SSU72 | PNAS-120 | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 | SSU72 | SSU72_HUMAN
Type:
Enzyme
Mol. Mass.:
22567.68
Organism:
Homo sapiens (Human)
Description:
Q9NP77
Residue:
194
Sequence:
MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY
  
Inhibitor
Name:
BDBM50607110
Synonyms:
CHEMBL5219519
Type:
Small organic molecule
Emp. Form.:
C9H9Br2NO4S
Mol. Mass.:
387.045
SMILES:
Cc1c(Br)cc(NC(=O)CS(O)(=O)=O)cc1Br
Structure:
Search PDB for entries with ligand similarity: