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Target
Proteinase-activated receptor 1
Ligand
BDBM50191039
Substrate
n/a
Meas. Tech.
ChEMBL_401364 (CHEMBL854222)
IC50
623±n/a nM
Citation
 Xia, Y; Chackalamannil, S; Chan, TM; Czarniecki, M; Doller, D; Eagen, K; Greenlee, WJ; Tsai, H; Wang, Y; Ahn, HS; Boykow, GC; McPhail, AT Himbacine derived thrombin receptor (PAR-1) antagonists: structure-activity relationship of the lactone ring. Bioorg Med Chem Lett 16:4969-72 (2006) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50191039
Synonyms:
6-methoxy-2-(2-((3R,3aS,4S,4aR,8aS,9aR)-3-methyl-dodecahydronaphtho[2,3-c]furan-4-yl)vinyl)quinoline | CHEMBL377594
Type:
Small organic molecule
Emp. Form.:
C25H31NO2
Mol. Mass.:
377.5191
SMILES:
COc1ccc2nc(\C=C\[C@@H]3[C@H]4[C@H](CO[C@@H]4C)C[C@@H]4CCCC[C@@H]34)ccc2c1
Structure:
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