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Target
Proteinase-activated receptor 1
Ligand
BDBM50191043
Substrate
n/a
Meas. Tech.
ChEMBL_401364 (CHEMBL854222)
IC50
5000±n/a nM
Citation
 Xia, Y; Chackalamannil, S; Chan, TM; Czarniecki, M; Doller, D; Eagen, K; Greenlee, WJ; Tsai, H; Wang, Y; Ahn, HS; Boykow, GC; McPhail, AT Himbacine derived thrombin receptor (PAR-1) antagonists: structure-activity relationship of the lactone ring. Bioorg Med Chem Lett 16:4969-72 (2006) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50191043
Synonyms:
(1R,3R,3aS,4R,5aS,9aR,9bS)-3-methyl-1-(quinolin-2-ylmethyl)-dodecahydronaphtho[2,1-c]furan-4-carboxylic acid | CHEMBL214862
Type:
Small organic molecule
Emp. Form.:
C24H29NO3
Mol. Mass.:
379.492
SMILES:
C[C@H]1O[C@H](Cc2ccc3ccccc3n2)C2[C@H]1[C@@H](C[C@@H]1CCCC[C@@H]21)C(O)=O
Structure:
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