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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50191612
Substrate
n/a
Meas. Tech.
ChEMBL_376271 (CHEMBL854480)
EC50
50±n/a nM
Citation
 Ahn, JH; Shin, MS; Jung, SH; Kang, SK; Kim, KR; Rhee, SD; Jung, WH; Yang, SD; Kim, SJ; Woo, JR; Lee, JH; Cheon, HG; Kim, SS Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. J Med Chem 49:4781-4 (2006) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50191612
Synonyms:
1-oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylicacid ethyl ester | CHEMBL210162
Type:
Small organic molecule
Emp. Form.:
C27H24O4
Mol. Mass.:
412.4771
SMILES:
CCOC(=O)C1=C(c2ccc(OCCCc3ccccc3)cc2C1=O)c1ccccc1 |t:5|
Structure:
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