Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM50196031
Substrate
n/a
Meas. Tech.
ChEMBL_416888 (CHEMBL909444)
Ki
25000±n/a nM
Citation
 Wang, G; Nikolovska-Coleska, Z; Yang, CY; Wang, R; Tang, G; Guo, J; Shangary, S; Qiu, S; Gao, W; Yang, D; Meagher, J; Stuckey, J; Krajewski, K; Jiang, S; Roller, PP; Abaan, HO; Tomita, Y; Wang, S Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem 49:6139-42 (2006) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50196031
Synonyms:
CHEMBL216213 | N-[(2-Tert-butyl-benzenesulfonyl)-phenyl]-2,3,4-trimethoxyl-5-(2-isopropyl-benzyl)-benzamide
Type:
Small organic molecule
Emp. Form.:
C36H41NO6S
Mol. Mass.:
615.779
SMILES:
COc1c(Cc2ccccc2C(C)C)cc(C(=O)Nc2ccc(cc2)S(=O)(=O)c2ccccc2C(C)(C)C)c(OC)c1OC
Structure:
Search PDB for entries with ligand similarity: