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Found 148 with Last Name = 'krajewski' and Initial = 'k'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University of Michigan

LigandPNGBDBM31202(JMC493432 Compound 8 | MI-63)
Affinity DataKi:  3nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196034(CHEMBL410802 | QEDIIRNIARHLAQVGDSMDR)
Affinity DataKi:  7nMAssay Description:Displacement of FAM-Bak from human Bcl-xL by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196034(CHEMBL410802 | QEDIIRNIARHLAQVGDSMDR)
Affinity DataKi:  11nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196034(CHEMBL410802 | QEDIIRNIARHLAQVGDSMDR)
Affinity DataKi:  12nMAssay Description:Displacement of FAM-Bid from human Mcl1 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University of Michigan

LigandPNGBDBM31198(spiro-oxindole, 4)
Affinity DataKi:  13nM ΔG°:  -44.7kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214871(1,4-bis(5,6,7-trihydroxy-8-isobutyl-2-methyl-4-oxo...)
Affinity DataKi:  17nMAssay Description:Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214871(1,4-bis(5,6,7-trihydroxy-8-isobutyl-2-methyl-4-oxo...)
Affinity DataKi:  18nMAssay Description:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13152((2S)-1-[(2S)-2-[(2S)-2-aminobutanamido]-3-methylbu...)
Affinity DataKi:  24nM ΔG°:  -43.1kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13151((2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylb...)
Affinity DataKi:  28nM ΔG°:  -42.7kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University of Michigan

LigandPNGBDBM31197(CHEMBL211045 | Nutlin-3 | med.21724, Compound 186)
Affinity DataKi:  36nM ΔG°:  -42.2kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University of Michigan

LigandPNGBDBM31199(spiro-oxindole, 5)
Affinity DataKi:  38nM ΔG°:  -42.1kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University of Michigan

LigandPNGBDBM31204(spiro-oxindole, 10)
Affinity DataKi:  39nM ΔG°:  -42.0kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University of Michigan

LigandPNGBDBM31201(spiro-oxindole, 7)
Affinity DataKi:  44nM ΔG°:  -41.7kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13155((2S)-1-[(2S)-2-[(2S)-2-aminobutanamido]-3-methylbu...)
Affinity DataKi:  81nM ΔG°:  -40.1kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University of Michigan

LigandPNGBDBM31196(spiro-oxindole, 1)
Affinity DataKi:  86nM ΔG°:  -40.1kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50208819(2-{2,3,4-trihydroxy-5-[methyl-(3-phenylpropyl)sulf...)
Affinity DataKi:  110nMAssay Description:Displacement of FAM-Bid BH3 peptide from human recombinant Bcl2 by FP-based binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50208819(2-{2,3,4-trihydroxy-5-[methyl-(3-phenylpropyl)sulf...)
Affinity DataKi:  150nMAssay Description:Displacement of FAM-Bid BH3 peptide from human Mcl1 by FP-based binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13150((2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylb...)
Affinity DataKi:  150nM ΔG°:  -38.6kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University of Michigan

LigandPNGBDBM31200(spiro-oxindole, 6)
Affinity DataKi:  170nM ΔG°:  -38.4kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  170nMAssay Description:Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13148((2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylb...)
Affinity DataKi:  180nM ΔG°:  -38.1kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  180nMAssay Description:Displacement of FAM-Bid from human Mcl1 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13147((2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylb...)
Affinity DataKi:  220nM ΔG°:  -37.6kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196032((N-[(2-tert-butylbenzenesulfonyl)phenyl]-2,3,4-tri...)
Affinity DataKi:  260nMAssay Description:Displacement of FAM-Bid from human Mcl1 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  280nMAssay Description:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13142((2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylb...)
Affinity DataKi:  290nM ΔG°:  -36.9kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13142((2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylb...)
Affinity DataKi:  290nM ΔG°:  -36.9kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196032((N-[(2-tert-butylbenzenesulfonyl)phenyl]-2,3,4-tri...)
Affinity DataKi:  290nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  320nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214872(5,6,7-trihydroxy-8-isobutyl-2-methyl-3-phenyl-chro...)
Affinity DataKi:  340nMAssay Description:Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13210((3S,6S,8aS)-6-[(2S)-2-aminobutanamido]-N-(diphenyl...)
Affinity DataKi:  350nM ΔG°:  -36.5kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214872(5,6,7-trihydroxy-8-isobutyl-2-methyl-3-phenyl-chro...)
Affinity DataKi:  400nMAssay Description:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  480nMAssay Description:Displacement of FAM-Bak from human Bcl-xL by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13200((2S,3S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamid...)
Affinity DataKi:  580nM ΔG°:  -35.2kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50208821(2-(2,3,4-trihydroxy-5-isopropylbenzoyl)-1,2,3,4-te...)
Affinity DataKi:  590nMAssay Description:Displacement of FAM-Bid BH3 peptide from human recombinant Bcl2 by FP-based binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50208819(2-{2,3,4-trihydroxy-5-[methyl-(3-phenylpropyl)sulf...)
Affinity DataKi:  638nMAssay Description:Displacement of FAM-Bak BH3 peptide from human Bcl-xL by FP-based binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214870(5,6,7-trihydroxy-8-isobutyl-2-methyl-4H-chromen-4-...)
Affinity DataKi:  730nMAssay Description:Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196036(CHEMBL217223 | N-(benzenesulfonyl-phenyl)-2,3,4-tr...)
Affinity DataKi:  930nMAssay Description:Displacement of FAM-Bid from human Bcl2 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50196032((N-[(2-tert-butylbenzenesulfonyl)phenyl]-2,3,4-tri...)
Affinity DataKi:  1.11E+3nMAssay Description:Displacement of FAM-Bak from human Bcl-xL by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13153((2S)-2-amino-N-[(2S)-3-methyl-1-oxo-1-[(2R)-2-(3-p...)
Affinity DataKi:  1.20E+3nM ΔG°:  -33.5kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214871(1,4-bis(5,6,7-trihydroxy-8-isobutyl-2-methyl-4-oxo...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of FAM-Bim peptide from human Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13146((2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylb...)
Affinity DataKi:  1.27E+3nM ΔG°:  -33.3kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13204((3S,6S,8aS)-6-[(2S)-2-aminobutanamido]-N-benzyl-5-...)
Affinity DataKi:  1.41E+3nM ΔG°:  -33.1kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50214870(5,6,7-trihydroxy-8-isobutyl-2-methyl-4H-chromen-4-...)
Affinity DataKi:  1.69E+3nMAssay Description:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13209((3S,6S,8aS)-6-[(2S)-2-aminopropanamido]-N-(dipheny...)
Affinity DataKi:  2.33E+3nM ΔG°:  -31.8kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50208820((3,4-dihydro-1H-isoquinolin-2-yl)-(2,3,4-trihydrox...)
Affinity DataKi:  3.10E+3nMAssay Description:Displacement of FAM-Bid BH3 peptide from human recombinant Bcl2 by FP-based binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University of Michigan

LigandPNGBDBM31203(spiro-oxindole, 9)
Affinity DataKi:  4.00E+3nM ΔG°:  -30.6kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13156((2S)-1-[(2S)-2-[(2S)-2-amino-3-methylbutanamido]-3...)
Affinity DataKi:  4.15E+3nM ΔG°:  -30.4kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13145((2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylb...)
Affinity DataKi:  4.41E+3nM ΔG°:  -30.3kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Michigan

LigandPNGBDBM13202((3S,6S,8aS)-6-[(2S)-2-aminopropanamido]-N-benzyl-5...)
Affinity DataKi:  4.47E+3nM ΔG°:  -30.2kJ/molepH: 7.5 T: 2°CAssay Description:A quantitative in vitro binding assay using the fluorescence polarization (FP) based method was developed and used to determine the binding affinity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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