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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50222176
Substrate
n/a
Meas. Tech.
ChEMBL_457757 (CHEMBL924033)
Ki
26000±n/a nM
Citation
 Boye, SV; Ortega-Caballero, F; Sinning, S; Wiborg, O; Jensen, HH; Bols, M High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors. Bioorg Med Chem Lett 17:6019-25 (2007) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50222176
Synonyms:
CHEMBL401069 | isopropyl 2-(3,4-dichlorophenyl)cyclopent-1-enecarboxylate
Type:
Small organic molecule
Emp. Form.:
C15H16Cl2O2
Mol. Mass.:
299.192
SMILES:
CC(C)OC(=O)C1=C(CCC1)c1ccc(Cl)c(Cl)c1 |t:6|
Structure:
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