TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 0.580nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant SERT expressed in african gree...More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 0.860nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant SERT expressed in african gree...More data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant DAT expressed in african green...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Binding affinity to NPY5 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Antagonist activity at rat NPY5 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant DAT expressed in african green...More data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant DAT expressed in african green...More data for this Ligand-Target Pair
Affinity DataKi: 2.80nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 3.5nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant SERT expressed in african gree...More data for this Ligand-Target Pair
Affinity DataKi: 3.90nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant DAT expressed in african green...More data for this Ligand-Target Pair
Affinity DataKi: 3.90nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant DAT expressed in african green...More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Displacement of [125I]RTI55 from human DAT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Inhibition of [3H]SER uptake in human SERT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 4.20nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant SERT expressed in african gree...More data for this Ligand-Target Pair
Affinity DataKi: 4.90nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.5nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant DAT expressed in african green...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Displacement of [125I]RTI55 from human SERT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 6.20nMAssay Description:Inhibition of serotonin transporterMore data for this Ligand-Target Pair
Affinity DataKi: 6.60nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant DAT expressed in african green...More data for this Ligand-Target Pair
Affinity DataKi: 6.70nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 7.5nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 8.5nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant NET expressed in african green...More data for this Ligand-Target Pair
Affinity DataKi: 8.80nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Inhibition of [3H]DA uptake in human DAT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Inhibition of [3H]DA uptake in human NET expressed in COS1 cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 13.9nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant DAT expressed in african green...More data for this Ligand-Target Pair
Affinity DataKi: 16.1nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 19nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant NET expressed in african green...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant NET expressed in african green...More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant DAT expressed in african green...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant SERT expressed in african gree...More data for this Ligand-Target Pair
Affinity DataKi: 21nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant DAT expressed in african green...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 21nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant SERT expressed in african gree...More data for this Ligand-Target Pair
Affinity DataKi: 21.5nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant NET expressed in african green...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Aarhus University
Curated by ChEMBL
Aarhus University
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Displacement of [125I]methyl 3-(4-iodophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate from human recombinant SERT expressed in african gree...More data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Displacement of [125I]RTI55 from human DAT transfected in COS1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Binding affinity to NPY5 receptorMore data for this Ligand-Target Pair