Reaction Details
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Neuropeptide Y receptor type 5
Ligand
BDBM50354075
Substrate
n/a
Meas. Tech.
ChEMBL_770872 (CHEMBL1837820)
Ki
13.9±n/a nM
Citation
Packiarajan, M; Marzabadi, MR; Desai, M; Lu, Y; Noble, SA; Wong, WC; Jubian, V; Chandrasena, G; Wolinsky, TD; Zhong, H; Walker, MW; Wiborg, O; Andersen, K Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder. Bioorg Med Chem Lett 21:5436-41 (2011) [PubMed] Article More Info.:
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
Inhibitor
Name:
BDBM50354075
Synonyms:
CHEMBL1836314
Type:
Small organic molecule
Emp. Form.:
C28H29N3O2S3
Mol. Mass.:
535.744
SMILES:
O=S(=O)(NC[C@H]1CC[C@@H](CC1)Nc1nc-2c(CCSc3ccccc-23)s1)c1cccc2ccccc12 |r,wU:5.4,wD:8.11,(6.06,-16.55,;4.52,-16.53,;5.31,-15.2,;3.19,-15.74,;3.21,-14.19,;1.88,-13.4,;.53,-14.15,;-.79,-13.37,;-.77,-11.83,;.57,-11.06,;1.9,-11.85,;-2.1,-11.04,;-3.45,-11.8,;-4.81,-11.18,;-5.82,-12.29,;-5.08,-13.59,;-5.7,-15.07,;-7.21,-15.46,;-8.42,-14.52,;-8.46,-12.92,;-9.85,-12.4,;-10.1,-10.94,;-8.95,-9.99,;-7.55,-10.51,;-7.31,-11.97,;-3.62,-13.29,;4.5,-18.07,;5.82,-18.85,;5.81,-20.39,;4.46,-21.16,;3.13,-20.36,;1.79,-21.11,;.47,-20.34,;.49,-18.79,;1.83,-18.04,;3.15,-18.82,)|
Structure:
