Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 4
Ligand
BDBM50269145
Substrate
n/a
Meas. Tech.
ChEMBL_528399 (CHEMBL974187)
IC50
>100000±n/a nM
Citation
 Brauers, G; Edrada, RA; Ebel, R; Proksch, P; Wray, V; Berg, A; Gräfe, U; Schächtele, C; Totzke, F; Finkenzeller, G; Marme, D; Kraus, J; Münchbach, M; Michel, M; Bringmann, G; Schaumann, K Anthraquinones and betaenone derivatives from the sponge-associated fungus Microsphaeropsis species: novel inhibitors of protein kinases. J Nat Prod 63:739-45 (2000) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50269145
Synonyms:
10-hydroxy-18-N-2-naphthyl-N-phenylaminobetaenone | CHEMBL443169
Type:
Small organic molecule
Emp. Form.:
C37H45NO5
Mol. Mass.:
583.7569
SMILES:
CCC(C)[C@H]1[C@](C)(O)C(=O)[C@@]2(O)C[C@](C)(O)C[C@@H](C)[C@@H]2[C@]1(C)C(=O)\C=C\N(c1ccccc1)c1ccc2ccccc2c1 |r|
Structure:
Search PDB for entries with ligand similarity: